ADC Matchup

Vayne vs Kai'Sa

Patch: 15.16 (25.16)
League: Platinum+
Vayne

Vayne

the Night Hunter
ADC
Vayne ADC Overall Win Rate
52.40%

Matchup Win Rate

52.5%
Vayne vs Kai'Sa Wins
⚔
47.5%
Kai'Sa vs Vayne Wins
Kai'Sa

Kai'Sa

Daughter of the Void
ADC
Kai'Sa ADC Overall Win Rate
50.14%

Vayne vs Kai'Sa - ADC Matchup Guide Patch 15.16 (25.16)

Vayne ADC vs Kai'Sa ADC - Who is stronger?

Vayne ADC has an advantage against Kai'Sa (52.5% win rate) based on 4513 games. The matchup leans toward Vayne.

View detailed statistics below: items, runes, and counter builds for Vayne ADC vs Kai'Sa ADC in patch 15.16 (25.16), including win rates and pick rates. With proper study, this can improve your chances of victory up to 64.6% in this matchup.

Statistical Matchup Analysis

With 7.0% popularity, Vayne constantly encounters meta-dominant Kai'Sa (18.1%, 2nd place out of 30 ADC champions). Understanding how to play against this popular champion becomes essential for consistent Vayne performance in the current patch. Meta strength confirmed: Vayne's superior tier rating (A+ vs A) translates into a solid 52.5% matchup win rate. This performance explains why Vayne ranks 6th in win rate among ADC champions. Vayne shows excellent consistency, combining a strong 52.4% overall win rate with matchup success. Optimize for consistency: Lethal Tempo paired with Triumph (58.1% win rate, 4.7% popularity) provides the stats you need, while the item sequence Blade of The Ruined King > Guinsoo's Rageblade > Wit's End with Berserker's Greaves delivers 64.6% win rate against Kai'Sa.

Win through macro: Vayne takes the matchup (52.53%) despite falling behind in CS (5.87 vs 7.89/min). Your victories come through roaming, team fighting, and map pressure rather than 1v1 lane dominance. Quality over quantity: Vayne wins through smart play rather than raw damage - despite lower DPS (812 vs 848/min), the 52.5% win rate shows superior utility, positioning, and team fight impact. Intriguing anomaly: Vayne wins the matchup (52.5%) despite a lower KDA (2.20 vs 2.60). This suggests you win through macro influence and clutch plays in key moments rather than consistent individual performance.

Vayne vs Kai'Sa - ADC Stats Comparison

Vayne ADC
Vayne ADC		Versus
Kai'Sa ADC
Kai'Sa ADC
A+TierA
52.5%Matchup Winrate47.5%
52.40%Role Winrate50.14%
#6Winrate Rank#19
7.0%Pickrate18.1%
2.2Average KDA2.6
427Gold per Minute456
5.87CS/Min7.89
0.29Wards per Minute0.32
812Damage per Minute848

How to Beat Kai'Sa as Vayne (ADC)

The Vayne versus Kai'Sa matchup as ADC is favorable with proper positioning. Use your statistical advantage and prevent the opponent from realizing their potential.

Except for rare builds, Vayne deals physical damage. Focus on eliminating enemy carries. Kai'Sa has mixed damage, be careful as it may be harder to defend if the opponent gets ahead or plays aggressively.

Consider the farming superiority demonstrated by Kai'Sa, ranking 3rd (versus 30th for Vayne) in farming efficiency among champions in this role. This means the opponent can build gold advantages more quickly. Meanwhile, their higher KDA (2.6 versus 2.2) suggests they participate more effectively in team fights.

Key aspects of the Vayne ADC versus Kai'Sa ADC matchup

Despite the statistical advantage in the matchup, overconfidence can be the main mistake. It is important for the Vayne player to maintain constant pressure on Kai'Sa, not allowing the opponent to safely scale up, and actively use the advantage gained to help their team.

Vayne vs Kai'Sa: ADC Summoner Spells

Most Popular

Flash
Flash Teleports you a short distance toward your cursor.
Barrier
Barrier Gain a brief Shield.
52.8% Win Rate83.9% Pick Rate

Highest Win Rate

Flash
Flash Teleports you a short distance toward your cursor.
Teleport
Teleport After a brief channel, become untargetable and travel to an allied unit. Upgrades into Unleashed Teleport, which significantly increases travel speed.
66.9% Win Rate0.1% Pick Rate

Vayne vs Kai'Sa: ADC Runes

Most Frequent Runes

Primary Path
Precision
Lethal Tempo
Lethal Tempo Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

Lethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds…

Triumph
Triumph Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.


'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Triumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant…

Legend: Alacrity
Legend: Alacrity Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 stacks).

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Legend: Alacrity

Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 sta…

Coup de Grace
Coup de Grace Deal 8% more damage to champions who have less than 40% health.

Coup de Grace

Deal 8% more damage to champions who have less than 40% health.

Secondary Path
Resolve
Conditioning
Conditioning After 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magic Resist by 3%.

Conditioning

After 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magi…

Overgrowth
Overgrowth Absorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.

When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.

Overgrowth

Absorb life essence from monsters or enemy minions that die near you, permanent…

Adaptive
Attack Speed
Attack Speed Increases attack speed by 10%

Attack Speed

Increases attack speed by 10%

Adaptive Force
Adaptive Force Grants 9 Attack Damage or 9 Ability Power

Adaptive Force

Grants 9 Attack Damage or 9 Ability Power

Scaling Health
Scaling Health Increases health from 10 to 180 HP across levels 1-18

Scaling Health

Increases health from 10 to 180 HP across levels 1-18

52.0% Win Rate77.7% Pick Rate

Best Win Rate Runes

Primary Path
Precision
Lethal Tempo
Lethal Tempo Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

Lethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds…

Triumph
Triumph Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.


'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Triumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant…

Legend: Alacrity
Legend: Alacrity Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 stacks).

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Legend: Alacrity

Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 sta…

Coup de Grace
Coup de Grace Deal 8% more damage to champions who have less than 40% health.

Coup de Grace

Deal 8% more damage to champions who have less than 40% health.

Secondary Path
Inspiration
Magical Footwear
Magical Footwear You get free Slightly Magical Footwear at 12 min, but you cannot buy boots before then. For each takedown you acquire the boots 45s sooner.

Slightly Magical Footwear grants you an additional 10 Move Speed.

Magical Footwear

You get free Slightly Magical Footwear at 12 min, but you cannot buy boots befo…

Biscuit Delivery
Biscuit Delivery Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 12% of your missing health. Consuming or selling a Biscuit permanently increases your max health by 30.

Biscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until …

Adaptive
Attack Speed
Attack Speed Increases attack speed by 10%

Attack Speed

Increases attack speed by 10%

Adaptive Force
Adaptive Force Grants 9 Attack Damage or 9 Ability Power

Adaptive Force

Grants 9 Attack Damage or 9 Ability Power

Scaling Health
Scaling Health Increases health from 10 to 180 HP across levels 1-18

Scaling Health

Increases health from 10 to 180 HP across levels 1-18

58.1% Win Rate4.7% Pick Rate

Vayne vs Kai'Sa: ADC Item Builds

Most Popular Build

Starting Items
Stealth Ward
Stealth Ward (0 gold) Active (210 - 120s, max 2 charges)
Places an Invisible Stealth Ward that grants vision for 90-120 seconds.
Doran's Blade
Doran's Blade (450 gold) 10 Attack Damage
80 Health
3% Life Steal
Health Potion
Health Potion (50 gold) Consume
Restores 120 Health over 15 seconds.
51.5% Win Rate96.6% Pick Rate
Popular Boots
Berserker's Greaves
Berserker's Greaves (1100 gold) 25% Attack Speed
45 Move Speed
52.1% Win Rate91.4% Pick Rate
Boots of Swiftness
Boots of Swiftness (1000 gold) 60 Move Speed
Fleetfooted
Reduce the effectiveness of Slows by 25%.
54.0% Win Rate2.3% Pick Rate
Plated Steelcaps
Plated Steelcaps (1200 gold) 25 Armor
45 Move Speed
Plating
Reduces incoming damage from Attacks by 10%.
48.5% Win Rate1.6% Pick Rate
Core Build
Vampiric Scepter
Vampiric Scepter (900 gold) 15 Attack Damage
7% Life Steal
->
Blade of The Ruined King
Blade of The Ruined King (3200 gold) 40 Attack Damage
25% Attack Speed
10% Life Steal
Mist's Edge
Attacks deal a percentage of enemy's current Health as bonus physical damageOn-Hit.
Clawing Shadows
Attacking a champion 3 times Slows them by 30% for 1 second.
Guinsoo's Rageblade
Guinsoo's Rageblade (3000 gold) 30 Attack Damage
30 Ability Power
25% Attack Speed
Wrath
Attacks deal 30 bonus magic damage On-Hit.
Seething Strike
Attacks grant 8% Attack Speed for 3 seconds. (stacks 4 times).
While fully stacked, every third Attack applies On-Hit effects twice.
Terminus
Terminus (3000 gold) 30 Attack Damage
35% Attack Speed
Shadow
Attacks deal 30 bonus magic damageOn-Hit.
Juxtaposition
Alternate between Light and Dark Attacks against champions:
  • Light Attacks grant Armor and Magic Resist for 5s.
  • Dark Attacks grant 10% Armor Penetration and Magic Penetration for 5s.
    • 61.8% Win Rate14.5% Pick Rate
    Final Build
    Jak'Sho, The Protean
    Jak'Sho, The Protean (3200 gold) 350 Health
    45 Armor
    45 Magic Resist
    Voidborn Resilience
    After 5 seconds of champion combat, increase your bonus Armor and Magic Resist by 30% until end of combat.
    62.0% Win Rate17.0% Pick Rate

    Best Win Rate Build

    Starting Items
    Stealth Ward
    Stealth Ward (0 gold) Active (210 - 120s, max 2 charges)
    Places an Invisible Stealth Ward that grants vision for 90-120 seconds.
    Long Sword
    Long Sword (350 gold) 10 Attack Damage
    Refillable Potion
    Refillable Potion (150 gold) Active (2 charges)
    Restores 100 Health over 12 seconds.
    Refills upon visiting the shop.
    70.3% Win Rate0.4% Pick Rate
    Highest Winrate Boots
    Mercury's Treads
    Mercury's Treads (1250 gold) 20 Magic Resist
    45 Move Speed
    30% Tenacity
    60.5% Win Rate0.8% Pick Rate
    Boots of Swiftness
    Boots of Swiftness (1000 gold) 60 Move Speed
    Fleetfooted
    Reduce the effectiveness of Slows by 25%.
    54.0% Win Rate2.3% Pick Rate
    Berserker's Greaves
    Berserker's Greaves (1100 gold) 25% Attack Speed
    45 Move Speed
    52.1% Win Rate91.4% Pick Rate
    Core Build
    Vampiric Scepter
    Vampiric Scepter (900 gold) 15 Attack Damage
    7% Life Steal
    ->
    Blade of The Ruined King
    Blade of The Ruined King (3200 gold) 40 Attack Damage
    25% Attack Speed
    10% Life Steal
    Mist's Edge
    Attacks deal a percentage of enemy's current Health as bonus physical damageOn-Hit.
    Clawing Shadows
    Attacking a champion 3 times Slows them by 30% for 1 second.
    Guinsoo's Rageblade
    Guinsoo's Rageblade (3000 gold) 30 Attack Damage
    30 Ability Power
    25% Attack Speed
    Wrath
    Attacks deal 30 bonus magic damage On-Hit.
    Seething Strike
    Attacks grant 8% Attack Speed for 3 seconds. (stacks 4 times).
    While fully stacked, every third Attack applies On-Hit effects twice.
    Wit's End
    Wit's End (2800 gold) 50% Attack Speed
    45 Magic Resist
    20% Tenacity
    Fray
    Attacks deal bonus magic damageOn-Hit.
    64.6% Win Rate7.8% Pick Rate
    Final Build
    Mercurial Scimitar
    Mercurial Scimitar (3200 gold) 40 Attack Damage
    40 Magic Resist
    10% Life Steal

    ACTIVE
    Quicksilver
    Removes all crowd control debuffs (excluding Airborne) and grants Move Speed.
    77.8% Win Rate8.5% Pick Rate
    Other Items
    Guardian Angel
    Guardian Angel (3200 gold) 55 Attack Damage
    45 Armor
    Rebirth
    Upon taking lethal damage, restores 50% base Health and 100% max Mana after 4 seconds of Stasis.
    44.8% Win Rate12.9% Pick Rate
    Mercurial Scimitar
    Mercurial Scimitar (3200 gold) 40 Attack Damage
    40 Magic Resist
    10% Life Steal

    ACTIVE
    Quicksilver
    Removes all crowd control debuffs (excluding Airborne) and grants Move Speed.
    77.8% Win Rate8.5% Pick Rate
    Bloodthirster
    Bloodthirster (3400 gold) 80 Attack Damage
    15% Life Steal
    Ichorshield
    Convert excess healing from your Lifesteal to a Shield.
    53.7% Win Rate7.6% Pick Rate
    Wit's End
    Wit's End (2800 gold) 50% Attack Speed
    45 Magic Resist
    20% Tenacity
    Fray
    Attacks deal bonus magic damageOn-Hit.
    62.7% Win Rate7.5% Pick Rate
    Phantom Dancer
    Phantom Dancer (2650 gold) 60% Attack Speed
    25% Critical Strike Chance
    8% Move Speed
    Spectral Waltz
    Become Ghosted.
    66.8% Win Rate6.9% Pick Rate
    Kraken Slayer
    Kraken Slayer (3100 gold) 45 Attack Damage
    40% Attack Speed
    4% Move Speed
    Bring It Down
    Every third Attack deals bonus physical damageOn-Hit, increased based on their missing Health.
    73.6% Win Rate3.3% Pick Rate
    Randuin's Omen
    Randuin's Omen (2700 gold) 350 Health
    75 Armor
    Resilience
    Receive 30% less damage from Critical Strikes.
    Humility
    Slow nearby enemies by 70% for 2 seconds.
    54.9% Win Rate3.0% Pick Rate

    Vayne vs Kai'Sa: ADC Skill (abilities) Orders

    Most Frequent Skill Order

    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    Q
    Q
    Tumble Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.
    Q
    Q
    Q
    Q
    Q
    W
    W
    Silver Bolts Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.
    W
    W
    W
    W
    W
    E
    E
    Condemn Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.
    E
    E
    E
    E
    E
    R
    R
    Final Hour Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter
    R
    R
    R
    Max Order: Q > W > E
    51.8% Win Rate71.4% Pick Rate

    Highest Win % Skill Order

    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    11
    12
    13
    14
    15
    16
    17
    18
    R
    Q
    Tumble Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.
    Q
    Q
    Q
    Q
    Q
    R
    W
    Silver Bolts Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.
    W
    W
    W
    W
    W
    R
    E
    Condemn Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.
    E
    E
    E
    E
    E
    R
    R
    Final Hour Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter
    R
    R
    R
    Max Order: Q > W > E
    62.2% Win Rate1.3% Pick Rate

    Vayne tips:

    • Tumble has many uses, but it cannot pass over walls.
    • Condemn can be used to both pin targets to walls to ensure a kill, or to escape a pursuer.
    • Don't go in first to a large teamfight. Wait for your teammates to initiate.

    Playing Against Kai'Sa

    • Kai'Sa is very good at picking off isolated enemies. Stick together against her.
    • Kai'Sa is very vulnerable to getting outranged by mages and long range carries.
    • Make sure to place wards in your blind spots so you can see Kai'Sa coming.

    Vayne ADC other Matchups

    Vayne
    +4.4%
    Ashe

    Vayne vs Ashe

    Vayne
    +3.8%
    Ezreal

    Vayne vs Ezreal

    Vayne
    +3.5%
    Jinx

    Vayne vs Jinx

    Vayne
    +3.2%
    Sivir

    Vayne vs Sivir

    Vayne
    +3.1%
    Zeri

    Vayne vs Zeri

    Vayne
    +2.6%
    Lucian

    Vayne vs Lucian

    Vayne
    +2.2%
    Varus

    Vayne vs Varus

    Vayne
    +2.0%
    Draven

    Vayne vs Draven

    Vayne
    +1.8%
    Tristana

    Vayne vs Tristana

    Vayne
    +1.8%
    Yunara

    Vayne vs Yunara

    Vayne
    +1.6%
    Jhin

    Vayne vs Jhin

    Vayne
    +1.3%
    Caitlyn

    Vayne vs Caitlyn

    Vayne
    +1.3%
    Miss Fortune

    Vayne vs Miss Fortune

    Vayne
    +1.2%
    Twitch

    Vayne vs Twitch

    Vayne
    +1.2%
    Corki

    Vayne vs Corki

    Vayne
    -1.2%
    Senna

    Vayne vs Senna

    Vayne
    -1.7%
    Xayah

    Vayne vs Xayah

    Vayne
    -2.0%
    Kog'Maw

    Vayne vs Kog'Maw

    Vayne
    -3.2%
    Nilah

    Vayne vs Nilah

    Vayne
    -3.4%
    Aphelios

    Vayne vs Aphelios

    Vayne
    -3.7%
    Ziggs

    Vayne vs Ziggs

    Vayne
    -3.8%
    Smolder

    Vayne vs Smolder

    Vayne
    -3.9%
    Samira

    Vayne vs Samira