Vayne ADC performs well against Senna (53.0% win rate) based on 684 games. This matchup works well for Vayne players.
View detailed statistics below: items, runes, and counter builds for Vayne ADC vs Senna ADC in patch 15.18 (25.18), including win rates and pick rates. With proper study, this can improve your chances of victory up to 60.0% in this matchup.
Balanced meta clash: Vayne (7.4%, 12th place out of 32 ADC champions) regularly faces Senna (3.0%, 20th place). Both champions hold solid meta positions, making this matchup knowledge a direct path to climbing and improving your win rate. Even tiers, uneven results: Both champions sit at A+-tier, but Vayne claims a meaningful 53.0% vs 47.0% advantage. Vayne's kit synergizes better in this specific head-to-head matchup. Vayne shows excellent consistency, combining a strong 52.2% overall win rate with matchup success. Optimize for consistency: Lethal Tempo paired with Triumph (54.0% win rate, 77.0% popularity) provides the stats you need, while the item sequence Blade of The Ruined King > Guinsoo's Rageblade > Terminus with Berserker's Greaves delivers 60.0% win rate against Senna.
Lane dominance: Vayne not only wins the matchup but crushes CS (6.69/min vs 6.41 for Senna). This 0.28 CS/min advantage generates significant gold leads that compound your already favorable position. Quality over quantity: Vayne wins through smart play rather than raw damage - despite lower DPS (778 vs 786/min), the 53.0% win rate shows superior utility, positioning, and team fight impact. Intriguing anomaly: Vayne wins the matchup (53.0%) despite a lower KDA (2.20 vs 3.10). This suggests you win through macro influence and clutch plays in key moments rather than consistent individual performance.
The Vayne versus Senna matchup as ADC is favorable with proper positioning. Use your statistical advantage and prevent the opponent from realizing their potential.
Except for rare builds, Vayne deals physical damage. Focus on eliminating enemy carries. Senna deals mainly physical damage (86.65%), additional items against this damage type may be required against snowballing or aggressive play.
An important advantage of Vayne is higher farming statistics (ranked 21st among role champions) (versus 24th for Senna), which provides a stable gold advantage in extended games and allows faster access to key items. Meanwhile, their higher KDA (3.1 versus 2.2) suggests they participate more effectively in team fights.
Despite the statistical advantage in the matchup, overconfidence can be the main mistake. It is important for the Vayne player to maintain constant pressure on Senna, not allowing the opponent to safely scale up, and actively use the advantage gained to help their team.
Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds…
Takedowns restore 5% of your missing health, 2.5% of your max health, and grant…
Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 sta…
Deal 8% more damage to champions who have less than 40% health.
After 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magi…
Absorb life essence from monsters or enemy minions that die near you, permanent…
Increases attack speed by 10%
Grants 9 Attack Damage or 9 Ability Power
Increases health from 10 to 180 HP across levels 1-18
Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds…
Takedowns restore 5% of your missing health, 2.5% of your max health, and grant…
Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 sta…
Deal 8% more damage to champions who have less than 40% health.
After 12 min gain +8 Armor and +8 Magic Resist and increase your Armor and Magi…
Absorb life essence from monsters or enemy minions that die near you, permanent…
Increases attack speed by 10%
Grants 9 Attack Damage or 9 Ability Power
Increases health from 10 to 180 HP across levels 1-18
