Dr. Mundo Top performs well against Vayne (53.0% win rate) based on 481 games. This matchup works well for Dr. Mundo players.
View detailed statistics below: items, runes, and counter builds for Dr. Mundo Top vs Vayne Top in patch 15.24 (25.24), including win rates and pick rates. With proper study, this can improve your chances of victory up to 62.0% in this matchup.
Dr. Mundo dominates the meta (10th most popular, 5.1% pick rate) and regularly clashes with Vayne (1.7% pick rate). Understanding this common matchup forms the foundation of consistent gameplay for one of top lane's current powerhouses. Even tiers, uneven results: Both champions sit at A+-tier, but Dr. Mundo claims a meaningful 53.0% vs 47.0% advantage. Dr. Mundo's kit synergizes better in this specific head-to-head matchup. Optimize for consistency: Fleet Footwork paired with Triumph (67.1% win rate, 1.7% popularity) provides the stats you need, while the item sequence Heartsteel > Warmog's Armor > Titanic Hydra with Boots of Swiftness delivers 62.0% win rate against Vayne.
Win through macro: Dr. Mundo takes the matchup (53.01%) despite falling behind in CS (6.48 vs 7.10/min). Your victories come through roaming, team fighting, and map pressure rather than 1v1 lane dominance. Quality over quantity: Dr. Mundo wins through smart play rather than raw damage - despite lower DPS (875 vs 898/min), the 53.0% win rate shows superior utility, positioning, and team fight impact. Statistical dominance: Dr. Mundo leads in both matchup win rate (53.0%) and KDA (1.90 vs 1.60) - complete superiority across all metrics.
| Dr. Mundo Top | Versus | Vayne Top |
|---|---|---|
| A+ | Tier | A+ |
| 53.0% | Matchup Winrate | 47.0% |
| 50.48% | Role Winrate | 51.68% |
| #23 | Winrate Rank | #9 |
| 5.1% | Pickrate | 1.7% |
| 1.9 | Average KDA | 1.6 |
| 393 | Gold per Minute | 431 |
| 6.48 | CS/Min | 7.10 |
| 0.30 | Wards per Minute | 0.32 |
| 875 | Damage per Minute | 898 |
The Dr. Mundo versus Vayne matchup in the top lane is favorable with proper positioning. Use your statistical advantage and prevent the opponent from realizing their potential.
Dr. Mundo deals mixed damage - the opponent has fewer options for defense. Vayne deals mainly physical damage (70.24%), additional items against this damage type may be required against snowballing or aggressive play.
Consider the farming superiority demonstrated by Vayne, ranking 12th (versus 34th for Dr. Mundo) in farming efficiency among champions in this role. This means the opponent can build gold advantages more quickly. Meanwhile, their lower KDA (1.6 versus 1.9) suggests they are less effective in team fights.
Despite the statistical advantage in the matchup, overconfidence can be the main mistake. It is important for the Dr. Mundo player to maintain constant pressure on Vayne, not allowing the opponent to safely scale up, and actively use the advantage gained to help their team.






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Charge up a powerful attack against a tower over 3s, while within 600 range of …

After taking damage from an enemy champion, heal for 4% of your missing health …

Absorb life essence from monsters or enemy minions that die near you, permanent…


You get free Slightly Magical Footwear at 12 min, but you cannot buy boots befo…

Gain 7.5% Move Speed towards nearby enemy champions that are movement impaired.…

Increases attack speed by 10%

Increases health from 10 to 180 HP across levels 1-18

Increases health from 10 to 180 HP across levels 1-18


Attacking and moving builds Energy stacks. At 100 stacks, your next attack is EnergizedEn…

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant…

Gain 1.5 basic ability haste for every Legend stack (max 10 stacks).Earn progre…

Deal 8% more damage to champions who have less than 40% health.


After taking damage from an enemy champion, heal for 4% of your missing health …

Absorb life essence from monsters or enemy minions that die near you, permanent…

Increases attack speed by 10%

Increases health from 10 to 180 HP across levels 1-18

Increases health from 10 to 180 HP across levels 1-18




























