Senna ADC has an advantage against Vayne (52.3% win rate) based on 684 games. The matchup leans toward Senna.
View detailed statistics below: items, runes, and counter builds for Senna ADC vs Vayne ADC in patch 15.16 (25.16), including win rates and pick rates. With proper study, this can improve your chances of victory up to 61.7% in this matchup.
Senna with 2.5% pick rate (21st place among ADC champions) rarely faces Vayne, who maintains 6.9% popularity. While this matchup isn't common overall, Vayne's solid presence in the meta makes understanding it worthwhile when you do play Senna. Optimize for consistency: Fleet Footwork paired with Presence of Mind (62.2% win rate, 24.6% popularity) provides the stats you need, while the item sequence Black Cleaver > Rapid Firecannon > Infinity Edge with Boots of Swiftness delivers 61.7% win rate against Vayne.
Win through macro: Senna takes the matchup (52.34%) despite falling behind in CS (5.70 vs 6.71/min). Your victories come through roaming, team fighting, and map pressure rather than 1v1 lane dominance. Complete superiority: Senna dominates both win rate (52.3%) and damage output (783 vs 755/min, 2nd among ADC). The 28 damage/min difference creates massive snowball potential. Statistical dominance: Senna leads in both matchup win rate (52.3%) and KDA (3.00 vs 2.20) - complete superiority across all metrics.
The Senna versus Vayne matchup as ADC is favorable with proper positioning. Use your statistical advantage and prevent the opponent from realizing their potential.
Except for rare builds, Senna deals physical damage. Focus on eliminating enemy carries. Vayne deals mainly physical damage (71.04%), additional items against this damage type may be required against snowballing or aggressive play.
Consider the farming superiority demonstrated by Vayne, ranking 18th (versus 28th for Senna) in farming efficiency among champions in this role. This means the opponent can build gold advantages more quickly. Meanwhile, their lower KDA (2.2 versus 3.0) suggests they are less effective in team fights.
Despite the statistical advantage in the matchup, overconfidence can be the main mistake. It is important for the Senna player to maintain constant pressure on Vayne, not allowing the opponent to safely scale up, and actively use the advantage gained to help their team.
Attacking and moving builds Energy stacks. At 100 stacks, your next attack is EnergizedEn…
Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.Take…
Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 sta…
Deal 8% more damage to champions who have more than 60% health.
Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until …
Gain 7.5% Move Speed towards nearby enemy champions that are movement impaired.…
Increases attack speed by 10%
Grants 9 Attack Damage or 9 Ability Power
+65 Health
Attacking and moving builds Energy stacks. At 100 stacks, your next attack is EnergizedEn…
Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.Take…
Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 sta…
Deal 8% more damage to champions who have more than 60% health.
Hitting an enemy champion with an ability permanently increases your maximum ma…
All movement bonuses are 7% more effective on you and gain 1% Move Speed.
Increases attack speed by 10%
Grants 9 Attack Damage or 9 Ability Power
+65 Health
